Lenalidomide hemihydrate
Lenalidomide hemihydrate is an oral immunomodulatory agent derived from thalidomide. It functions by binding to cereblon (CRBN), the substrate receptor of the CRL4 ubiquitin ligase complex, leading to the targeted ubiquitination and degradation of the transcription factors IKZF1 and IKZF3. This mechanism underpins its extensive use in research for hematological malignancies and immunology, both in vitro and in vivo.
Product Specifications
CAS Number
847871-99-2
Product Name Alternative
Cereblon, Cereblon, CC-5013 hemihydrate, degradation, CRL4, Apoptosis, analog, ligand, LigandforE3Ligase, Ligand for E3 Ligase, ligase, Ligands for E3 Ligase, inhibit, myeloma, multiple, immunomodulatory, Molecular Glues, MolecularGlues, Inhibitor, IKZF1, IKZF3, Lenalidomide, Lenalidomide Hemihydrate, Lenalidomide hemihydrate, E3 ligase-recruiting Moiety, TNF-α
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
96.22% (May vary between batches)
Solubility
DMSO:Soluble
Smiles
O=C (C (N (CC1=C2C=CC=C1N) C2=O) CC3) NC3=O.O=C (C (N (CC4=C5C=CC=C4N) C5=O) CC6) NC6=O.[H]O[H]
Molecular Formula
C13H13N3O3.1/2H2O
Molecular Weight
268.28
Storage Conditions
-20°C
Notes
For research use only.
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