BMS-833923
BMS-833923 (XL-139) is a potent, orally bioavailable antagonist of the Smoothened (SMO) receptor, exhibiting an IC50 of 21 nM in displacing BODIPY-cyclopamine. This small molecule is a valuable tool for investigating Hedgehog pathway signaling in both cellular and animal models of cancer and developmental biology.
Product Specifications
CAS Number
1059734-66-5
Product Name Alternative
Smo, Smoothened, XL139, XL-139, XL 139, Hedgehog, inhibit, Inhibitor, Apoptosis, BMS833923, BMS-833923, BMS 833923
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.47% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.97 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:88 mg/mL (185.82 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CNCc1ccc (C) c (NC (=O) c2ccc (Nc3nc (-c4ccccc4) c4ccccc4n3) cc2) c1
Molecular Formula
C30H27N5O
Molecular Weight
473.57
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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