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CNX-774

CNX-774 is a potent, orally bioavailable, and irreversible small molecule inhibitor of Bruton's tyrosine kinase (BTK) with sub-nanomolar inhibitory activity. It is a valuable research tool for investigating BTK-dependent signaling pathways in both cellular assays and animal models of autoimmune diseases and B-cell malignancies.

Product Specifications

CAS Number

1202759-32-7

Product Name Alternative

Inhibitor, inhibit, CNX774, CNX-774, CNX 774, autoimmune, Bruton tyrosine kinase, BTK, Btk, B-cell, BCR

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Purity

97.35% (May vary between batches)

Solubility

Ethanol:2 mg/mL (4 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.61 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:93 mg/mL (186.19 mM)

Smiles

CNC (=O) c1cc (Oc2ccc (Nc3ncc (F) c (Nc4cccc (NC (=O) C=C) c4) n3) cc2) ccn1

Molecular Formula

C26H22FN7O3

Molecular Weight

499.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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