MRT-10
MRT10 is a smoothened (Smo) receptor antagonist with an IC50 of 0.5 μM, demonstrated by its inhibition of BODIPY-cyclopamine binding in murine Smo-expressing HEK293 cells. This small molecule is a valuable tool for investigating Hedgehog signaling pathway mechanisms in both cellular and animal models of development and disease.
Product Specifications
CAS Number
330829-30-6
Product Name Alternative
ShhN signaling, Smoothened, Smo, Smo-induced IP accumulation, SAG-induced AP activity, Bodipy-cyclopamine, cancer, inhibit, MRT10, MRT-10, MRT 10, Hedgehog, Inhibitor
Field of Research
Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Purity
99.47% (May vary between batches)
Solubility
DMSO:40 mg/mL (85.93 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (4.3 mM)
Smiles
COc1cc (cc (OC) c1OC) C (=O) NC (=S) Nc1cccc (NC (=O) c2ccccc2) c1
Molecular Formula
C24H23N3O5S
Molecular Weight
465.52
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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