CHIR-99021
CHIR-99021 is a potent, selective, and orally active GSK-3α/β inhibitor that activates Wnt/β-catenin signaling. It is widely used in stem cell research to promote self-renewal of embryonic stem cells by inducing autophagy, and has applications in studies of development, metabolism, and regeneration in vitro and in vivo.
Product Specifications
CAS Number
252917-06-9
Product Name Alternative
Beta catenin, beta-catenin, betacatenin, CHIR 99021, CHIR99021, CHIR-99021, CT99021, CT-99021, CT 99021, Autophagy, bcatenin, Laduviglusib, Inhibitor, Glycogen synthase kinase 3, Glycogen synthase kinase-3, GSK-3β, GSK-3α, GSK3, GSK-3, inhibit, βcatenin, β-catenin, Wnt, Wnt/β-catenin, Wnt/b-catenin, Wnt/betacatenin
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
≥95% (May vary between batches)
Solubility
DMSO: 105 mg/mL (225.64 mM), Sonication is recommended.
Smiles
Cc1c[nH]c (n1) -c1cnc (NCCNc2ccc (cn2) C#N) nc1-c1ccc (Cl) cc1Cl
Molecular Formula
C22H18Cl2N8
Molecular Weight
465.34
Storage Conditions
-20°C
Notes
For research use only.
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