CD8A (Cytotoxic / Suppressor T-Cell Marker) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[CD8A]
NCBI Gene ID
925
Reactivity
Human
Storage Conditions
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a protein of 32kDa, identified as CD8a (also known as CD8 chain, T cell co-receptor, Leu2, and T8). CD8 molecule consists of two chains, termed and chain, which are expressed as a disulphide-linked heterodimer or as an homodimer. CD8 is expressed on T cell subset (cytotoxic/suppressor T cells), thymocytes and NK cells. The majority of CD8+ T-cells expresses CD8 as heterodimer. Some subpopulation of CD8+ T cells as well as NK cells may express homodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 chain (but not chain). The cytoplasmic domain of CD8 associates with p56lck tyrosine kinase.
Other Gene Names
[CD8A; CD8A; CD8; MAL; p32; Leu2; MAL]
Short Name
[CD8A]
Other Product Names
[T-cell surface glycoprotein CD8 alpha chain isoform 1; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 alpha chain; CD8a molecule; T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a]
NCBI GI Number
225007536
NCBI Accession Number
NP_001139345.1
NCBI GB Accession Number
NM_001145873.1
Uniprot Accession Number
P01732
CAS Number
9007-83-4
Available Sizes
Curated Selection
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