PF-431396
PF-431396 is a potent small molecule inhibitor targeting both PYK2 and FAK kinases, with IC50 values of 11 nM and 2 nM, respectively. It is a valuable research tool for studying focal adhesion dynamics and has been utilized in both in vitro and in vivo models to investigate cancer cell migration, invasion, and metastasis.
Product Specifications
CAS Number
717906-29-1
Product Name Alternative
Proline-rich tyrosine kinase 2, PTK2, PTK2 protein tyrosine kinase 2, PF431396, PF-431396, PF 431396, Pyk2, PYK2, inhibit, Inhibitor, Focal adhesion kinase, FAK
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.48% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.95 mM) ; DMSO:25.3 mg/mL (49.95 mM)
Smiles
CN (c1ccccc1CNc1nc (Nc2ccc3NC (=O) Cc3c2) ncc1C (F) (F) F) S (C) (=O) =O
Molecular Formula
C22H21F3N6O3S
Molecular Weight
506.5
Storage Conditions
-20°C
Notes
For research use only.
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