Alkaline Phosphatase (Placental) / PLAP (Germ Cell Tumor Marker) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[ALPP]
NCBI Gene ID
250
Reactivity
Human
Storage Conditions
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the gestational trophoblastic disease.
Other Gene Names
[ALPP; ALPP; ALP; PALP; PLAP; PLAP-1; PLAP; PLAP-1]
Short Name
[Alkaline Phosphatase / PLAP]
Other Product Names
[alkaline phosphatase, placental type preproprotein; Alkaline phosphatase, placental type; alkaline phosphatase, placental type; alkaline phosphatase, placental; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1]
NCBI GI Number
94721246
NCBI Accession Number
NP_001623.3
NCBI GB Accession Number
NM_001632.4
Uniprot Accession Number
P05187
CAS Number
9007-83-4
Available Sizes
Curated Selection
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