SR1664
SR1664 is a potent, selective PPARγ inhibitor that blocks Cdk5-mediated phosphorylation (IC50 = 80 nM) without agonist activity. This tool compound is used in diabetes research to study PPARγ's role in insulin sensitization in both cellular and animal models.
Product Specifications
CAS Number
1338259-05-4
Product Name Alternative
S273, stereospecificity, SR 1664, SR1664, SR-1664, phosphorylation, PPARγ, PPAR, Peroxisome proliferator-activated receptors, clash, dependent, inhibit, Inhibitor, HEK293T, F282
Field of Research
Metabolism Research, Molecular Biology
Purity
98.02% (May vary between batches)
Solubility
DMSO:60 mg/mL (109.57 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.65 mM)
Smiles
C[C@H] (NC (=O) c1ccc2n (Cc3ccc (cc3) -c3ccccc3C (O) =O) c (C) c (C) c2c1) c1ccc (cc1) [N+] ([O-]) =O
Molecular Formula
C33H29N3O5
Molecular Weight
547.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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