Cytokeratin, pan (Epithelial Marker) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[KRT77]
NCBI Gene ID
374454
Reactivity
Human, Monkey, Cow, Dog, Rabbit, Mouse, Rat, Chicken
Storage Conditions
Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months.,Non-hazardous. No MSDS required.
Specificity
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Other Gene Names
[KRT77; KRT77; K1B; KRT1B; KRT1B; CK-1B; K77]
Short Name
[Cytokeratin, pan]
Other Product Names
[keratin, type II cytoskeletal 1b; Keratin, type II cytoskeletal 1b; keratin, type II cytoskeletal 1b; keratin 77; Cytokeratin-1B; CK-1B; Keratin-77; K77; Type-II keratin Kb39]
NCBI GI Number
194018511
NCBI Accession Number
NP_778253.2
NCBI GB Accession Number
NM_175078.2
Uniprot Accession Number
Q7Z794
CAS Number
9007-83-4
Available Sizes
Curated Selection
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