HLA-DRB (MHC II) Mouse Monoclonal Antibody

Antibody <b>with</b> azide: Store at 2°C to 8°C.<br>Antibody <b>without</b> azide: Store at -20°C to -80°C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.

This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the SPM289 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional AP's. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.

[major histocompatibility complex, class II, DR beta 1; HLA class II histocompatibility antigen, DRB1-15 beta chain; major histocompatibility complex, class II, DR beta 1; major histocompatibility complex, class II, DR beta 1; DW2.2/DR2.2; MHC class II antigen DRB1*15]