(Z) -Semaxinib
(Z) -Semaxinib (SU5416) is a selective quinolone-based inhibitor of VEGFR2 (Flk-1/KDR) with an IC50 of 1.23 μM, exhibiting over 20-fold selectivity against PDGFRβ and no activity on FGFR, InsR, or EGFR. This antineoplastic agent has been utilized in research to study angiogenesis and tumor growth in both cellular assays and animal models.
Product Specifications
CAS Number
194413-58-6
Product Name Alternative
Cytotoxicity, c-Met/HGFR, (Z) Semaxinib, (Z) -Semaxanib, (Z) Semaxinib, (Z) -SU5416, HepG2 cells, Inhibitor, inhibit, Semaxinib, TAMH cells, SU5416, SU-5416, SU 5416, VEGFR2/Flk1
Field of Research
Cardiovascular Research, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:7.14 mg/mL (29.96 mM) ; Ethanol:2 mg/mL (8.39 mM)
Smiles
C (=C\1/C=2C (NC1=O) =CC=CC2) \C=3NC (C) =CC3C
Molecular Formula
C15H14N2O
Molecular Weight
238.28
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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