AR-13324 analog (mesylate)

AR-13324 analog mesylate is an analog of AR-13324. AR-13324 is an ROCK and norepinephrine transporter (NET) inhibitor[1].

Product Specifications

CAS Number

[2095432-73-6]

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ar-13324-analog-mesylate.html

Concentration

10mM

Purity

98.0

Solubility

10 mM in DMSO|DMSO : ≥ 28 mg/mL

Smiles

CS(=O)(O)=O.CS(=O)(O)=O.O=C(OC1=CC=C([C@@H](CN)C(NC2=CC3=C(C=NC=C3)C=C2)=O)C=C1)C4=CC=C(C)C=C4C

Molecular Formula

C29H33N3O9S2

Molecular Weight

631.72

References & Citations

[1]Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24 (1) :51-4.|[2]Levy B, et al. Ocular hypotensive safety and systemic absorption of AR-13324 ophthalmic solution in normal volunteers. Am J Ophthalmol. 2015 May;159 (5) :980-5.e1.|[3]Wang RF, et al. Effect of 0.04% AR-13324, a ROCK, and norepinephrine transporter inhibitor, on aqueous humor dynamics in normotensive monkey eyes. J Glaucoma. 2015 Jan;24 (1) :51-4.