5J-4
5J-4 is a potent and selective inhibitor of the CRAC channel, effectively suppressing store-operated calcium entry (SOCE) . This action leads to reduced IL-17 production and downregulation of the transcription factors RORα and RORγt, making it a valuable tool for studying Th17 cell biology and related autoimmune pathologies in both cellular and animal models.
Product Specifications
CAS Number
827001-82-1
Product Name Alternative
5J 4, 5J4, 5J-4, Calcium release-activated channels, Calcium Channel, Ca2+ release-activated Ca2+ channels, CRAC channel, CRAC Channel, CNS, CD4+ cells, CalciumChannel, Inhibitor, inhibit, inflammation, mononuclear cell, experimental autoimmune encephalomyelitis
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
96.12% (May vary between batches)
Solubility
DMSO:50 mg/mL (160.08 mM)
Smiles
OC1=CC=C2C (NC (=S) NC (=O) C3=CC=CO3) =CC=CC2=C1
Molecular Formula
C16H12N2O3S
Molecular Weight
312.34
Storage Conditions
-20°C
Notes
For research use only.
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