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5J-4

5J-4 is a potent and selective inhibitor of the CRAC channel, effectively suppressing store-operated calcium entry (SOCE) . This action leads to reduced IL-17 production and downregulation of the transcription factors RORα and RORγt, making it a valuable tool for studying Th17 cell biology and related autoimmune pathologies in both cellular and animal models.

Product Specifications

CAS Number

827001-82-1

Product Name Alternative

5J 4, 5J4, 5J-4, Calcium release-activated channels, Calcium Channel, Ca2+ release-activated Ca2+ channels, CRAC channel, CRAC Channel, CNS, CD4+ cells, CalciumChannel, Inhibitor, inhibit, inflammation, mononuclear cell, experimental autoimmune encephalomyelitis

Field of Research

Metabolism Research, Pharmacology & Drug Discovery

Purity

96.12% (May vary between batches)

Solubility

DMSO:50 mg/mL (160.08 mM)

Smiles

OC1=CC=C2C (NC (=S) NC (=O) C3=CC=CO3) =CC=CC2=C1

Molecular Formula

C16H12N2O3S

Molecular Weight

312.34

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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