Binimetinib
Binimetinib (ARRY-162) is an orally bioavailable, selective MEK1/2 inhibitor (IC50=12 nM) . It exhibits antitumor activity and is used in research for unresectable or BRAF V600E/K mutant metastatic melanoma. Its application extends to in vitro signaling studies and in vivo xenograft models investigating MAPK pathway inhibition.
Product Specifications
CAS Number
606143-89-9
Product Name Alternative
ARRY-162; MEK162
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Purity
>98%
Bioactivity
MEK1/2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to at least 25 mg/ml)
Smiles
Cn1cnc2c (F) c (Nc3ccc (Br) cc3F) c (cc12) C (=O) NOCCO
Molecular Formula
C17H15BrF2N4O3
Molecular Weight
441.23
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
6- (4-Bromo-2-fluoroanilino) -7-fluoro-N- (2-hydroxyethoxy) -3-methylbenzimidazole-5-carboxamide
Available Sizes
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