Ensifentrine
Ensifentrine is a dual PDE3/4 inhibitor with a strong preference for PDE3 (IC50: 0.4 nM), being over 3,000-fold more selective for this isoform than for PDE4. This investigational small molecule is being studied in clinical trials for obstructive respiratory diseases, including COPD and asthma, with supporting evidence from in vitro and in vivo preclinical research.
Product Specifications
CAS Number
1884461-72-6
Product Name Alternative
Phosphodiesterase (PDE), RPL 554, RPL554, RPL-554, PDE3, PDE4, inhaled, inhibit, Inhibitor, Ensifentrinum, Ensifentrina, Ensifentrine, COPD, anti-inflammatory, bronchoprotective
Field of Research
Metabolism Research
Purity
98.45% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.09 mM) ; DMSO:20 mg/mL (41.88 mM)
Smiles
COc1cc2CCn3c (c\c (=N/c4c (C) cc (C) cc4C) n (CCNC (N) =O) c3=O) -c2cc1OC
Molecular Formula
C26H31N5O4
Molecular Weight
477.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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