CD33
Product Specifications
Gene Name
[CD33]
NCBI Gene ID
945
Reactivity
Human.
Storage Conditions
Store at 2 to 8 °C. Antibody is stable for 24 months.
Specificity
Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
Other Gene Names
[CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]
Short Name
[CD33]
Other Product Names
[myeloid cell surface antigen CD33 isoform 2; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]
NCBI GI Number
130980072
NCBI Accession Number
NP_001076087.1
NCBI GB Accession Number
NM_001082618.1
Uniprot Accession Number
P20138
Available Sizes
Curated Selection
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