Lumacaftor
Lumacaftor (VRT 826809) is a small molecule corrector that facilitates the proper folding and cellular trafficking of the F508del-CFTR protein, with an EC50 of 100 nM in FRT cells. It is a key research tool for studying cystic fibrosis mechanisms in vitro and has been evaluated in preclinical in vivo models to assess CFTR correction and function.
Product Specifications
CAS Number
936727-05-8
Product Name Alternative
VX809, VX-809, VRT 826809, VRT826809, VRT-826809, VX 809, inhibit, Lumacaftor, Inhibitor, F508del-CFTR, Cystic fibrosis transmembrane conductance regulator, CFTR, Autophagy
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
99.48% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:6 mg/mL (13.26 mM) ; DMSO:247 mg/mL (545.96 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (11.05 mM)
Smiles
Cc1ccc (NC (=O) C2 (CC2) c2ccc3OC (F) (F) Oc3c2) nc1-c1cccc (c1) C (O) =O
Molecular Formula
C24H18F2N2O5
Molecular Weight
452.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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