Spebrutinib
Spebrutinib (LMK-435) is an oral, selective, and irreversible inhibitor of Bruton's tyrosine kinase (BTK) . It is utilized in preclinical research for studying B-cell malignancies and autoimmune diseases, demonstrating activity in both cellular assays and animal models.
Product Specifications
CAS Number
1202757-89-8
Product Name Alternative
Yes, Spebrutinib, AVL 292, AVL292, AVL-292, Bruton tyrosine kinase, Btk, BTK, CC292, CC-292, CC 292, BRK, c-Src, inhibit, LMK 435, LMK435, LMK-435, Lyn, Inhibitor
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.02% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.72 mM) ; DMSO:79 mg/mL (186.57 mM)
Smiles
COCCOc1ccc (Nc2ncc (F) c (Nc3cccc (NC (=O) C=C) c3) n2) cc1
Molecular Formula
C22H22FN5O3
Molecular Weight
423.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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