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SNS-314 mesylate

SNS-314 Mesylate is a potent and selective pan-Aurora kinase inhibitor, demonstrating high specificity for Aurora A, B, and C with IC50 values of 9, 31, and 3 nM, respectively. It has shown reduced activity against several off-target kinases, including TrkA/B and Fms. This compound is a valuable chemical probe for investigating Aurora kinase biology in cellular and in vivo cancer models.

Product Specifications

CAS Number

1146618-41-8

Product Name Alternative

PC-3, HT29, H-1299, A2780, AuroraKinase, Aurora Kinase, Aurora C, Aurora B, Aurora A, ovarian cancer cell, SNS-314, SNS314 Mesylate, SNS-314 Mesylate, SNS 314 Mesylate

Field of Research

Cell Biology, Epigenetics & Chromatin

Purity

>98%

Bioactivity

Aurora kinase inhibitor

Form

Powder

Solubility

Soluble in DMSO (up to at least 25 mg/ml)

Smiles

CS (O) (=O) =O.Clc1cccc (NC (=O) Nc2ncc (CCNc3ncnc4ccsc34) s2) c1

Molecular Formula

C18H15ClN6OS2·CH3SO3H

Molecular Weight

527.04

Storage Conditions

-20°C

Notes

For research use only.

Other Product Names

1- (3-Chlorophenyl) -3-[5-[2- (thieno[3,2-d]pyrimidin-4-ylamino) ethyl]-1,3-thiazol-2-yl]urea mesylate

Available Sizes

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