LGK974
LGK974 (NVP-LGK974) is a potent and selective PORCN inhibitor that blocks Wnt signaling with an IC50 of 0.4 nM in TM3 cells. It has been investigated in clinical trials for cancers such as metastatic colorectal carcinoma and head and neck squamous cell carcinoma, based on preclinical in vivo and in vitro studies.
Product Specifications
CAS Number
1243244-14-5
Product Name Alternative
LGK 974, LGK974, LGK-974, NVP-LGK 974, NVP-LGK974, NVP-LGK-974, WNT974, WNT-974, WNT 974, Porcn
Field of Research
Stem Cell & Developmental Biology
Purity
≥98% (May vary between batches)
Solubility
DMSO:16.96 mg/mL (42.78 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (8.32 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cc (ccn1) -c1ncc (CC (=O) Nc2ccc (cn2) -c2cnccn2) cc1C
Molecular Formula
C23H20N6O
Molecular Weight
396.44
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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