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LGK974

LGK974 (NVP-LGK974) is a potent and selective PORCN inhibitor that blocks Wnt signaling with an IC50 of 0.4 nM in TM3 cells. It has been investigated in clinical trials for cancers such as metastatic colorectal carcinoma and head and neck squamous cell carcinoma, based on preclinical in vivo and in vitro studies.

Product Specifications

CAS Number

1243244-14-5

Product Name Alternative

LGK 974, LGK974, LGK-974, NVP-LGK 974, NVP-LGK974, NVP-LGK-974, WNT974, WNT-974, WNT 974, Porcn

Field of Research

Stem Cell & Developmental Biology

Purity

≥98% (May vary between batches)

Solubility

DMSO:16.96 mg/mL (42.78 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (8.32 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

Cc1cc (ccn1) -c1ncc (CC (=O) Nc2ccc (cn2) -c2cnccn2) cc1C

Molecular Formula

C23H20N6O

Molecular Weight

396.44

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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