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G-749

G-749 is a novel, potent small-molecule FLT3 inhibitor effective against both wild-type and mutant FLT3 kinases. It demonstrates sustained inhibitory activity, making it a valuable research tool for investigating acute myeloid leukemia (AML) in both cellular and animal models.

Product Specifications

CAS Number

1457983-28-6

Product Name Alternative

CRET, Denfivontinib, drug, Cluster of differentiation antigen 135, CD135, acute, Apoptosis, AML, Aurora Kinase, AuroraKinase, Aurora B, inhibit, kinase, myeloid, Mer, Fms-like, Fms like tyrosine kinase 3, FLT3, FLT3 (D835Y), G 749, G749, G-749, Inhibitor, leukemia, tyrosine, TAMReceptor, TAM Receptor, resistance, RET, receptor

Field of Research

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction

Purity

98.32% (May vary between batches)

Solubility

DMSO:< 1 mg/mL (insoluble or slightly soluble) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Smiles

CN1CCC (CC1) Nc1nc (Nc2ccc (Oc3ccccc3) cc2) c2c (n1) c (Br) c[nH]c2=O

Molecular Formula

C25H25BrN6O2

Molecular Weight

521.41

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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