UNC2881
UNC2881 is a potent and selective small molecule inhibitor of Mer tyrosine kinase (MERTK), exhibiting an IC50 of 4.3 nM with 83-fold and 58-fold selectivity over Axl and Tyro3, respectively. This inhibitor is a valuable research tool for studying MERTK signaling in oncology and immunology, applicable in both in vitro cellular assays and in vivo model systems.
Product Specifications
CAS Number
1493764-08-1
Product Name Alternative
Axl, AXL, Mer, Inhibitor, inhibit, pathologic thrombosis, orally active, platelet aggregation, TAM Receptor, TAMReceptor, phosphorylation, Tyro3, UNC2881, UNC-2881, UNC 2881
Field of Research
Infectious Disease & Virology, Signal Transduction
Purity
98.97% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.12 mM) ; DMSO:85 mg/mL (183.36 mM) ; Ethanol:5 mg/mL (10.79 mM)
Smiles
CCCCNc1ncc (C (=O) NCc2ccc (cc2) -n2ccnc2) c (NC2CCC (O) CC2) n1
Molecular Formula
C25H33N7O2
Molecular Weight
463.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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