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Triparanol

Triparanol (NSC-65345) is a research compound that inhibits Hedgehog signaling by disrupting the post-translational modification of its ligands and the sterol-sensing domain of PTCH1. It has demonstrated antitumor activity in human models and functions as an antilipemic agent, though it is noted for significant ocular toxicity.

Product Specifications

CAS Number

78-41-1

Product Name Alternative

Apoptosis, 24-DHCR, cholesterol biosynthesis, Hedgehog, Inhibitor, MER 29, MER29, MER-29, inhibit, NSC65345, NSC-65345, NSC 65345, Smoothened, PTCH1, Triparanol, tumor growth

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology

Purity

99.72% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.28 mM) ; DMSO:50 mg/mL (114.16 mM)

Smiles

C (CC1=CC=C (Cl) C=C1) (O) (C2=CC=C (OCCN (CC) CC) C=C2) C3=CC=C (C) C=C3

Molecular Formula

C27H32ClNO2

Molecular Weight

438

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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