Cytokeratin 17 (KRT17) (Basal Epithelial Marker) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[KRT17]
NCBI Gene ID
3872
Reactivity
Human, Rat, Cow, Goat, Pig
Storage Conditions
Antibody without azide - Store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Cytokeratin 17 (CK17) is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glands such as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as -epithelial stem cell- marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
Other Gene Names
[KRT17; KRT17; PC; K17; PC2; 39.1; CK-17; PCHC1; CK-17; K17]
Short Name
[Cytokeratin 17 (KRT17)]
Other Product Names
[keratin, type I cytoskeletal 17; Keratin, type I cytoskeletal 17; keratin, type I cytoskeletal 17; keratin 17; 39.1; Cytokeratin-17; CK-17; Keratin-17; K17]
NCBI GI Number
4557701
NCBI Accession Number
NP_000413.1
NCBI GB Accession Number
NM_000422.2
Uniprot Accession Number
Q04695
CAS Number
9007-83-4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
