GSK429286A
GSK429286A is a potent and selective ROCK1/2 inhibitor with IC50 values of 14 nM and 63 nM, respectively. It is widely used in research to investigate Rho/ROCK signaling pathways in cellular processes such as cytoskeletal regulation, and has been applied in both in vitro and in vivo models of neurological and cardiovascular function.
Product Specifications
CAS Number
864082-47-3
Product Name Alternative
Inhibitor, inhibit, GSK429286A, GSK-429286A, ROCK, ROK, ROCK1, ROCK2, Rho-kinase, RHO 15, RHO15, RHO-15, Rho-associated kinase, Rho-associated protein kinase
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.68% (May vary between batches)
Solubility
Ethanol:4 mg/mL (9.25 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.63 mM) ; DMSO:140 mg/mL (323.8 mM)
Smiles
CC1=C (C (CC (=O) N1) c1ccc (cc1) C (F) (F) F) C (=O) Nc1cc2cn[nH]c2cc1F
Molecular Formula
C21H16F4N4O2
Molecular Weight
432.37
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog