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GSK429286A

GSK429286A is a potent and selective ROCK1/2 inhibitor with IC50 values of 14 nM and 63 nM, respectively. It is widely used in research to investigate Rho/ROCK signaling pathways in cellular processes such as cytoskeletal regulation, and has been applied in both in vitro and in vivo models of neurological and cardiovascular function.

Product Specifications

CAS Number

864082-47-3

Product Name Alternative

Inhibitor, inhibit, GSK429286A, GSK-429286A, ROCK, ROK, ROCK1, ROCK2, Rho-kinase, RHO 15, RHO15, RHO-15, Rho-associated kinase, Rho-associated protein kinase

Field of Research

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Purity

97.68% (May vary between batches)

Solubility

Ethanol:4 mg/mL (9.25 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.63 mM) ; DMSO:140 mg/mL (323.8 mM)

Smiles

CC1=C (C (CC (=O) N1) c1ccc (cc1) C (F) (F) F) C (=O) Nc1cc2cn[nH]c2cc1F

Molecular Formula

C21H16F4N4O2

Molecular Weight

432.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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