Decernotinib
Decernotinib (VX-509) is a potent and selective JAK3 inhibitor with a Ki of 2.5 nM. It demonstrates cellular activity (IC50 50-170 nM) and has been investigated in preclinical models of autoimmune diseases, including rheumatoid arthritis, for its immunomodulatory effects.
Product Specifications
CAS Number
944842-54-0
Product Name Alternative
Inhibit, JAK3, Janus kinase, JAK1, JAK2, JAK, Inhibitor, Decernotinib, VX 509, VX509, VX-509, VRT831509, VRT-831509, VRT 831509, TyrosineKinases, Tyrosine Kinases, Tyk2
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.28% (May vary between batches)
Solubility
Ethanol:16 mg/mL (40.78 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.1 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:250 mg/mL (637.14 mM)
Smiles
CC[C@@] (C) (Nc1ccnc (n1) -c1c[nH]c2ncccc12) C (=O) NCC (F) (F) F
Molecular Formula
C18H19F3N6O
Molecular Weight
392.38
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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