LY2811376
LY2811376 is a potent and orally bioavailable small molecule BACE1 inhibitor with an IC50 of 239-249 nM, reducing Aβ secretion (EC50: 300 nM) . It shows high selectivity over BACE2 and other aspartic proteases, making it a valuable tool for in vitro and in vivo Alzheimer's disease research.
Product Specifications
CAS Number
1194044-20-6
Product Name Alternative
Beta Amyloid, BetaAmyloid, b Amyloid, Aβ, bAmyloid, BACE, BACE1, b-Secretase, bSecretase, BetaSecretase, Beta-secretase, inhibit, LY 2811376, LY2811376, LY-2811376, Inhibitor, β-Secretase, βSecretase, βAmyloid, β Amyloid
Field of Research
Neuroscience
Purity
95.23% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:13 mg/mL (40.58 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.24 mM) ; Ethanol:60 mg/mL (187.29 mM)
Smiles
C[C@]1 (CCSC (N) =N1) c1cc (c (F) cc1F) -c1cncnc1
Molecular Formula
C15H14F2N4S
Molecular Weight
320.36
Storage Conditions
-20°C
Notes
For research use only.
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