CD171/ NCAM-L1
Product Specifications
Gene Name
[L1CAM]
NCBI Gene ID
3897
Reactivity
Human.
Storage Conditions
Antibody with azide store at 2 to 8°C. Antibody without azide store at -20 to -80°C
Specificity
Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.
Other Gene Names
[L1CAM; L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; CAML1; MIC5; N-CAM-L1; NCAM-L1]
Short Name
[CD171]
Other Product Names
[neural cell adhesion molecule L1 isoform 1; Neural cell adhesion molecule L1; neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1; L1 cell adhesion molecule; CD_antigen: CD171]
NCBI GI Number
4557707
NCBI Accession Number
NP_000416.1
NCBI GB Accession Number
NM_000425.4
Uniprot Accession Number
P32004
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
