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CD171/ NCAM-L1

Product Specifications

Gene Name

[L1CAM]

NCBI Gene ID

3897

Reactivity

Human.

Storage Conditions

Antibody with azide store at 2 to 8°C. Antibody without azide store at -20 to -80°C

Specificity

Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.

Other Gene Names

[L1CAM; L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; CAML1; MIC5; N-CAM-L1; NCAM-L1]

Short Name

[CD171]

Other Product Names

[neural cell adhesion molecule L1 isoform 1; Neural cell adhesion molecule L1; neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1; L1 cell adhesion molecule; CD_antigen: CD171]

NCBI GI Number

4557707

NCBI Accession Number

NP_000416.1

NCBI GB Accession Number

NM_000425.4

Uniprot Accession Number

P32004

Available Sizes

Frequently Asked Questions

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