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Ixazomib

Ixazomib (MLN2238) is a second-generation, boron-containing proteasome inhibitor that potently targets the chymotrypsin-like (β5) activity of the 20S proteasome, with additional inhibition of its caspase-like (β1) and trypsin-like (β2) sites. It is widely used in preclinical research, including in vitro cell-based assays and in vivo xenograft models, for studying multiple myeloma and other malignancies.

Product Specifications

CAS Number

1072833-77-2

Product Name Alternative

20S proteasome, caspase-like (β1), Autophagy, Inhibitor, inhibit, Ixazomib, MLN 2238, MLN2238, MLN-2238, Proteasome

Field of Research

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Purity

98.00% (May vary between batches)

Solubility

Ethanol:9 mg/mL (24.93 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.54 mM) ; DMSO:55 mg/mL (152.34 mM)

Smiles

CC (C) C[C@H] (NC (=O) CNC (=O) c1cc (Cl) ccc1Cl) B (O) O

Molecular Formula

C14H19BCl2N2O4

Molecular Weight

361.03

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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