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LY2109761

LY2109761 is a potent and selective dual inhibitor of TGF-β receptor types I and II (TβRI/II), with respective Ki values of 38 nM and 300 nM. It effectively blocks Smad2 phosphorylation and is widely used in vitro and in vivo to study TGF-β signaling in cancer, fibrosis, and immunology research.

Product Specifications

CAS Number

700874-71-1

Product Name Alternative

Smad, TβRI, TβRII, Transforming growth factor beta receptors, TGF-β/Smad, TGF-β Receptor, TGFβ, TGF-beta, TGFbeta/Smad, TGFbeta, TGFb, TGF-b/Smad, Autophagy, Inhibitor, inhibit, LY2109761, LY-2109761, LY 2109761

Field of Research

Cell Biology, Stem Cell & Developmental Biology

Purity

97.00% (May vary between batches)

Solubility

Ethanol:Insoluble; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.26 mM) ; DMSO:6.88 mg/mL (15.58 mM)

Smiles

C (CN1CCOCC1) Oc1ccc2c (ccnc2c1) -c1c2CCCn2nc1-c1ccccn1

Molecular Formula

C26H27N5O2

Molecular Weight

441.52

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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