p53 Tumor Suppressor Protein Mouse Monoclonal Antibody
Product Specifications
Gene Name
[TP53]
NCBI Gene ID
7157
Reactivity
Human, Monkey, Cow.<br>Others not known
Storage Conditions
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Other Gene Names
[TP53; TP53; P53; BCC7; LFS1; TRP53; P53]
Short Name
[p53 Tumor Suppressor Protein]
Other Product Names
[cellular tumor antigen p53 isoform a; Cellular tumor antigen p53; cellular tumor antigen p53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53]
NCBI GI Number
120407068
NCBI Accession Number
NP_000537.3
NCBI GB Accession Number
NM_000546.5
Uniprot Accession Number
P04637
CAS Number
9007-83-4
Available Sizes
Curated Selection
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