BIX02189
BIX02189 is a potent, selective small-molecule inhibitor of the MEK5-ERK5 signaling pathway, exhibiting IC50 values of 1.5 nM for MEK5 and 59 nM for ERK5. This compound is a valuable research tool for investigating the role of this pathway in cancer, inflammation, and cardiovascular diseases in both cellular and animal models.
Product Specifications
CAS Number
1265916-41-3
Product Name Alternative
BIX02189, BIX-02189, BIX 02189, ERK, Extracellular signal regulated kinases, Inhibitor, MEK, MAP2K, MAPKK, Mitogen-activated protein kinase kinase, inhibit
Field of Research
Signal Transduction
Purity
97.84% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.54 mM) ; DMSO:49.4 mg/mL (112.14 mM)
Smiles
CN (C) Cc1cccc (N\C (=C2/C (=O) Nc3cc (ccc23) C (=O) N (C) C) c2ccccc2) c1
Molecular Formula
C27H28N4O2
Molecular Weight
440.54
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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