Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Mouse Monoclonal Antibody

Product Specifications

CAS Number

9007-83-4

Gene Name

[CCND1]

NCBI Gene ID

595

Reactivity

Human, Monkey, Mouse, Rat

Storage Conditions

Antibody with azide - store at 2°C to 8°C. Non-hazardous. No MSDS required.

Specificity

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). About 40% of breast carcinomas are positive for Cyclin D1. Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

Other Gene Names

[CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1]

Short Name

[Cyclin D1]

Other Product Names

[G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; cyclin D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene]