UNC 569 hydrochloride
UNC 569 hydrochloride is a potent, ATP-competitive inhibitor of Mer (IC50=2.9 nM; Ki=4.3 nM), with additional activity against Axl and Tyro3. It is a valuable research tool for studying the role of TAM kinases in cancers such as acute lymphoblastic leukemia and atypical teratoid/rhabdoid tumors in experimental models.
Product Specifications
Product Name Alternative
1350547-65-7, 1350547-65-7 Free base, AXL, Mer, TAMReceptor, TAM Receptor, Tyro3, UNC 569 hydrochloride, UNC 569 Hydrochloride, UNC 569 hydrochloride (1350547-65-7 Free base), UNC-569 Hydrochloride, UNC569 Hydrochloride
Field of Research
Signal Transduction
Purity
99.93% (May vary between batches)
Solubility
0.1M HCl:6 mg/mL (13.86 mM) ; DMSO:3.61 mg/mL (8.34 mM)
Smiles
CCCCNC1=NC=C (C2=N1) C (C3=CC=C (F) C=C3) =NN2C[C@@H]4CC[C@@H] (N) CC4.Cl
Molecular Formula
C22H30ClFN6
Molecular Weight
432.96
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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