Tyrosinase (Melanoma Marker) Mouse Monoclonal Antibody
Product Specifications
Gene Name
[TYR]
NCBI Gene ID
7299
Reactivity
Human.Others not known.
Storage Conditions
Antibody with azide- store at 2-8°C
Specificity
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Other Gene Names
[TYR]
Short Name
[Tyrosinase]
Other Product Names
[tyrosinase; Tyrosinase; LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB]
NCBI GI Number
4507753
NCBI GB Accession Number
NM_000372.4
Uniprot Accession Number
P14679
CAS Number
9007-83-4
Available Sizes
Curated Selection
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