Amsilarotene
Amsilarotene (TAC101) induces cell cycle arrest by inhibiting retinoblastoma (RB) protein phosphorylation and upregulating CDK inhibitors. It also exerts cytotoxic effects through downregulation of thymidylate synthase and cyclin A. This mechanism supports its research application in studying cancer cell proliferation in both in vitro and in vivo models.
Product Specifications
CAS Number
125973-56-0
Product Name Alternative
Am 555S, BxPC-3, cancer, AsPC-1, Amsilarotene, Apoptosis, CDK, inhibit, MIAPaCa-2, Inhibitor, Retinoic acid receptors, Retinoid X receptors, RMG-II, TAC 101, TAC101, TAC-101, RAR/RXR, orally active
Field of Research
Cell Biology, Metabolism Research
Purity
98.05% (May vary between batches)
Solubility
DMSO:60 mg/mL (155.6 mM) ; H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.19 mM)
Smiles
C[Si] (C) (C) c1cc (cc (c1) [Si] (C) (C) C) C (=O) Nc1ccc (cc1) C (O) =O
Molecular Formula
C20H27NO3Si2
Molecular Weight
385.6
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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