HBX 41108
HBX 41108 is a reversible, non-competitive USP7 inhibitor with an IC50 of 424 nM, which effectively blocks USP7-mediated p53 deubiquitination (IC50 = 0.8 μM) . This compound is a valuable research tool for studying the p53 pathway and USP7 biology in cancer and neurodegenerative disease models, both in vitro and in vivo.
Product Specifications
CAS Number
924296-39-9
Product Name Alternative
Apoptosis, Deubiquitinase, DUBs, Inhibitor, HBX 41108, HBX41108, HBX-41108, p53, inhibit, USP7
Field of Research
Cell Biology, Molecular Biology, Protein Biochemistry
Purity
95.63% (May vary between batches)
Solubility
DMSO:60 mg/mL (225.02 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.75 mM)
Smiles
Clc1ccc-2c (c1) C (=O) c1nc (C#N) c (nc-21) C#N
Molecular Formula
C13H3ClN4O
Molecular Weight
266.64
Storage Conditions
-20°C
Notes
For research use only.
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