AP-18
AP-18 is a potent, selective TRPA1 antagonist, inhibiting cinnamaldehyde- and AITC-induced activation in vitro (IC50 ~3-10 μM) . It demonstrates in vivo efficacy by reversing CFA-induced mechanical hyperalgesia in mice, making it a valuable research tool for studying pain and inflammation pathways.
Product Specifications
CAS Number
55224-94-7
Product Name Alternative
Dorsal, AP 18, AP18, AP-18, ganglia, hyperalgesia, Inhibitor, inhibit, pain, nociceptive, nerves, TRP Channel, TRPA1, TRPChannel, TRPV Channel, TRPVChannel, transduction, Transient receptor potential channels, root
Field of Research
Neuroscience
Purity
>98%
Bioactivity
TRPA1 blocker
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml) .
Smiles
C\C (=C/c1ccc (Cl) cc1) \C (\C) =N\O
Molecular Formula
C11H12ClNO
Molecular Weight
209.7
Storage Conditions
RT
Notes
For research use only.
Other Product Names
4- (4-Chlorophenyl) -3-methylbut-3-en-2-oxime
Available Sizes
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