Fedratinib
Fedratinib is a potent, selective, and orally bioavailable ATP-competitive inhibitor of JAK2 and JAK2V617F. It induces apoptosis in tumor cells and is used in research for myeloproliferative neoplasms, with studies demonstrating efficacy in both cellular assays and animal models.
Product Specifications
CAS Number
936091-26-8
Product Name Alternative
CRET, anti-cancer, anti-proliferation, Apoptosis, orally, JAK2, JAK, JAK2 (V617F), JAK2V617F, Janus kinase, myeloproliferative, Inhibitor, inhibit, FLT3, Fedratinib, phosphorylation, STAT5, SAR 302503, SAR302503, SAR-302503, RET, TG101348, TG-101348, TG 101348
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
97.31% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:240 mg/mL (457.42 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:9.3 mg/mL (17.73 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
Cc1cnc (Nc2ccc (OCCN3CCCC3) cc2) nc1Nc1cccc (c1) S (=O) (=O) NC (C) (C) C
Molecular Formula
C27H36N6O3S
Molecular Weight
524.68
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
110500W1-AAT 500 Tests
MFluor™ Red 780 Anti-mouse CD105 Antibody *MJ7/18*
Sign In for Pricing
View Details 
C4693 96 Tests
Coiled-coil domain-containing protein 154 (CCDC154) Human ELISA Kit
Sign In for Pricing
View Details 