PF-4708671
PF-4708671 is a potent and cell-permeable small molecule inhibitor targeting the S6K1 isoform of p70 ribosomal S6 kinase, with a Ki50 of 20 nM and an IC50 of 160 nM in biochemical assays. It is widely used in research to investigate mTOR/S6K signaling pathways in cellular models of metabolism, growth, and cancer, and has been employed in both in vitro and in vivo experimental settings.
Product Specifications
CAS Number
1255517-76-0
Product Name Alternative
Inhibitor, inhibit, p70 S6K, Autophagy, PF4708671, PF-4708671, PF 4708671, S6 Kinase, S6K, S6Kinase, Ribosomal S6 Kinase (RSK)
Field of Research
Cell Biology, Signal Transduction
Purity
99.41% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM) ; DMSO:19.5 mg/mL (49.95 mM) ; Ethanol:19.5 mg/mL (49.95 mM)
Smiles
CCc1cncnc1N1CCN (Cc2nc3cc (ccc3[nH]2) C (F) (F) F) CC1
Molecular Formula
C19H21F3N6
Molecular Weight
390.41
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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