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GSK-923295

GSK923295 is a potent and selective allosteric inhibitor of the mitotic kinesin CENP-E, with a reported inhibition constant (Ki) of 3.2 nM. It is a valuable chemical probe for studying mitosis, aneuploidy, and has been utilized in both in vitro biochemical assays and in vivo tumor xenograft models to investigate antimitotic therapies.

Product Specifications

CAS Number

1088965-37-0

Product Name Alternative

CENP-E, Apoptosis, Inhibitor, GSK 923295, GSK923295, GSK-923295, Kinesin, inhibit

Field of Research

Cell Biology, Signal Transduction

Purity

96.22% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.22 mM) ; DMSO:93 mg/mL (157.06 mM) ; Ethanol:93 mg/mL (157.06 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)

Smiles

CC (C) Oc1ccc (cc1Cl) C (=O) N[C@H] (CNC (=O) CN (C) C) Cc1ccc (cc1) -c1cn2cccc ([C@H] (C) O) c2n1

Molecular Formula

C32H38ClN5O4

Molecular Weight

592.13

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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