GSK-923295
GSK923295 is a potent and selective allosteric inhibitor of the mitotic kinesin CENP-E, with a reported inhibition constant (Ki) of 3.2 nM. It is a valuable chemical probe for studying mitosis, aneuploidy, and has been utilized in both in vitro biochemical assays and in vivo tumor xenograft models to investigate antimitotic therapies.
Product Specifications
CAS Number
1088965-37-0
Product Name Alternative
CENP-E, Apoptosis, Inhibitor, GSK 923295, GSK923295, GSK-923295, Kinesin, inhibit
Field of Research
Cell Biology, Signal Transduction
Purity
96.22% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (4.22 mM) ; DMSO:93 mg/mL (157.06 mM) ; Ethanol:93 mg/mL (157.06 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CC (C) Oc1ccc (cc1Cl) C (=O) N[C@H] (CNC (=O) CN (C) C) Cc1ccc (cc1) -c1cn2cccc ([C@H] (C) O) c2n1
Molecular Formula
C32H38ClN5O4
Molecular Weight
592.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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