ML347
ML347 is a potent and selective small molecule inhibitor of ALK1 and ALK2 kinases, with IC50 values of 46 nM and 32 nM, respectively. It demonstrates over 300-fold selectivity for ALK2 over ALK3. This inhibitor is a valuable research tool for studying BMP signaling in fibrodysplasia ossificans progressiva (FOP) models and other related pathways in both cellular and in vivo contexts.
Product Specifications
CAS Number
1062368-49-3
Product Name Alternative
TGF-β/Smad, TGF-β Receptor, TGFβ, Transforming growth factor beta receptors, Smad, Smad1/5, TGFbeta, TGF-b/Smad, TGFb, TGF-beta, TGFbeta/Smad, ML 347, ML347, ML-347, Inhibitor, inhibit, LDN193719, LDN-193719, LDN 193719, ALK6, ALK1, ALK2, ALK3
Field of Research
Cardiovascular Research, Signal Transduction, Stem Cell & Developmental Biology
Purity
≥95% (May vary between batches)
Solubility
DMSO:1 mg/mL (2.84 mM)
Smiles
COc1ccc (cc1) -c1cnc2c (cnn2c1) -c1cccc2ncccc12
Molecular Formula
C22H16N4O
Molecular Weight
352.39
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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