PND-1186
PND-1186 (VS-4718) is a potent, reversible, and selective focal adhesion kinase (FAK) inhibitor with an IC50 of 1.5 nM. It is a valuable research tool for investigating FAK's role in cancer cell migration, proliferation, and survival in both in vitro and in vivo models.
Product Specifications
CAS Number
1061353-68-1
Product Name Alternative
Apoptosis, cell, growth, Focal adhesion kinase, FAK, Inhibitor, integrin, inhibit, PTK2, PTK2 protein tyrosine kinase 2, SR2516, SR-2516, SR 2516, survival, PND1186, PND-1186, PND 1186, VS 4718, VS4718, VS-4718, tumor
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
≥98% (May vary between batches)
Solubility
DMSO:34 mg/mL (67.8 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.99 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CNC (=O) c1ccccc1Nc1cc (Nc2ccc (cc2OC) N2CCOCC2) ncc1C (F) (F) F
Molecular Formula
C25H26F3N5O3
Molecular Weight
501.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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