Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

UCPH-102

UCPH-102 is a highly selective EAAT1 inhibitor with an IC50 of 0.43 µM. UCPH-102 exhibits a specific anti-proliferative effect on T-ALL cells. UCPH-102 also shows good blood-brain permeability, which can be used in studies of amyotrophic lateral sclerosis, Alzheimer’s disease, chronic pain and obsessive compulsive disorder[1][2][3][4].

Product Specifications

CAS Number

1229591-56-3

Product Name Alternative

SKQ1

UNSPSC

12352005

Target

EAAT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ucph-102.html

Purity

99.20

Solubility

DMSO : 8 mg/mL (ultrasonic; warming)

Smiles

N#CC1=C(OC(CC(C2)C3=C4C=CC=CC4=CC=C3)=C(C1C)C2=O)N

Molecular Formula

C21H18N2O2

Molecular Weight

330.38

References & Citations

[1]Huynh TH, et al. Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. Bioorg Med Chem. 2012 Dec 1;20 (23) :6831-9.|[2]Haym I, et al. Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102. ChemMedChem. 2016 Feb 17;11 (4) :403-19.|[3]Stanulović V S, et al. Proliferation and Survival of T-cell Acute Lymphoblastic Leukaemia Depends on mTOR-regulated Glutamine Uptake and EAAT1-dependent Conversion of Glutamine to Aspartate and Nucleotides. bioRxiv. 2020. |[4]Abrahamsen B, et al. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. J Neurosci. 2013 Jan 16;33 (3) :1068-87.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EAAT1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Texas Red Conjugated Phaseolus vulgaris Lectin (Red Kidney Bean) -PHA-E-
T-1802-2 2 mg

Texas Red Conjugated Phaseolus vulgaris Lectin (Red Kidney Bean) -PHA-E-

Sign In for Pricing
View Details
PHF14 Human Gene Knockout Kit (CRISPR)
KN424565 1 Kit

PHF14 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
ANKRD2 Antibody
KC-44457-01 50 μL

ANKRD2 Antibody

Sign In for Pricing
View Details
ANKRD2 Antibody
KC-44457-02 100 µL

ANKRD2 Antibody

Sign In for Pricing
View Details
ANKRD2 Antibody
KC-44457-03 1 mL

ANKRD2 Antibody

Sign In for Pricing
View Details
UGT8 Human Gene Knockout Kit (CRISPR)
KN210442 1 Kit

UGT8 Human Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details