L-779450
L-779450 is a potent and selective ATP-competitive inhibitor of Raf kinase with an IC50 of 10 nM. It exhibits strong selectivity, showing over 70-fold, 30-fold, and 7-fold preference for Raf over Lck, GSK3β, and p38α, respectively. This inhibitor is a valuable tool for investigating Raf-mediated signaling pathways in cancer research, both in cellular and biochemical assays.
Product Specifications
CAS Number
303727-31-3
Product Name Alternative
Autophagy, L779450, L-779450, Inhibitor, L 779450, inhibit, Raf, Raf kinases
Field of Research
Cell Biology, Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
DMSO:60 mg/mL (172.51 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.75 mM)
Smiles
Oc1cc (ccc1Cl) -c1[nH]c (nc1-c1ccncc1) -c1ccccc1
Molecular Formula
C20H14ClN3O
Molecular Weight
347.8
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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